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Pregnant Pause for Elephant

Recent news from the Indianapolis Zoo was mammoth: the first baby African elephant conceived through artificial insemination was delivered successfully. IU School of Medicine's Mark Deeg, MD, PhD, played a role.

Dr. Deeg, an endocrinologist and assistant professor in the Department of Medicine, and technician Suzie Huffed were responsible for conducting hormonal assays before the mother elephant, Kubwa, was inseminated and throughout the two?year gestation period.

"Blood samples were evaluated for progesterone levels over the course of the elephant's reproductive cycle," Dr. Deeg explains. "Changes in levels induce ovulation, which in African elephants occurs every other menstrual cycle."

Kubwa's progesterone level was monitored weekly after conception. As the gestation cycle neared the two?year mark, Dr. Deeg watched for a drop in that level, a sign that birth is approaching.

How do you get an African elephant pregnant? The usual way But elephant moms in captivity may need an assist. Only twenty-seven African elephants have been born in North America since they were first imported in the nineteenth century, according to Indianapolis Zoo officials. That's why many zoos are turning to artificial insemination.

Dr. Deeg said the School's endocrinology section has worked with zoos in Atlanta, Memphis, Pittsburgh, Miami and New York City on research and other projects related to metabolic monitoring of animals.