High School Students Get Benchside View of Human Genetics

Unraveling the mysteries of human genetics and understanding how research can lead to the treatment and cures of genetic diseases shouldn't be confined to classroom lectures and textbooks.

After all, explaining life and its processes requires a lively presentation - and that's exactly what forty-eight students from throughout the state received at the Molecular Medicine in Action Program at the Indiana University Cancer Research Institute, March 12-13.

The students, selected from more than 350 applicants nominated by their high school teachers, worked side by side at laboratory stations with IU School of Medicine researchers and physicians in one of the most modern cancer research centers in the country.

"We focused on genetic research so students would understand the roles genes play in disease and how scientists might develop ways to correct genetic flaws," says David A. Williams, MD '79, director of the Herman B Wells Center for Pediatric Research at Riley Hospital for Children, and Freida and Albrecht Kipp Professor of Pediatrics.

"We wanted to get more students excited about science and interested in science careers," he adds. Dr. Williams is also an associate investigator with the Howard Hughes Medical Institute. "We hope this annual conference will help us build new and stronger ties with teachers and students across the state."

Under the supervision of scientists, small groups of students rotated through workstations and laboratory sites. They learned how DNA - the building blocks of life - is isolated and analyzed for mutations that are associated with diseases, and discovered how virus vectors could be used in gene therapies. One module offered students the opportunity to work with computer simulations to fathom the mechanisms by which retroviruses infect cells and incorporate genes into those cells.

The students also learned about the human side of research. Dr. Williams interviewed patients with Fanconi anemia, a genetic disorder. The purpose was to demonstrate the importance of gathering the medical history and gaining the perspective of patients. Related modules showed the young scientists how blood cells develop in Fanconi sufferers. Another demonstrated how bone marrow transplants can help patients.

"Our goal was to share the new frontiers of cutting-edge research," says Lilith Reeves, MS, who along with Dr. Williams co-chaired the Molecular Medicine in Action program. "We loaned these young people the tools to learn; they provided the vision."

The two-day event wasn't all science and lab work. On the evening of their arrival, the students were recognized at a special dinner and were welcomed by Gerald L. Bepko, chancellor of Indiana University-Purdue University Indianapolis. They also attended a science career fair and were entertained by a local rock band.

The Herman B Wells Center for Pediatric Research, IU School of Medicine, Clarian Health, Indiana University-Purdue University Indianapolis, Indiana Department of Education, Indiana Association of Biology Teachers, Hoosier Association of Science Teachers and Riley Memorial Association provided logistical and financial support.