Winter 04

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News and Notes

New Wishard CEO Brings Wealth of Experience to Job

A clinician for more than two decades, Lisa E. Harris, MD, has served her patients well and compassionately. That experience certainly will help her in her new role as chief executive officer and medical director of Wishard Health Services.

Dr. Harris assumed the top role of one of the nation’s largest public hospitals in late December, following her appointment by the trustees of the Health and Hospital Corporation of Marion County and IUSM Dean D. Craig Brater, MD. The Milwaukee-born doctor was chief of medicine at Wishard and executive vice president and chief medical officer for IU Medical Group-Primary Care at the time of her appointment. She succeeds Robert B. Jones, MD, PhD, who was appointed executive associate dean for strategic planning, analysis and operations at the School.

“Dr. Harris brings a tremendous wealth of experience as a clinician and manager,” Dr. Brater says. “Her breadth of experience, coupled with having practiced medicine at Wishard her entire medical career, means she is uniquely equipped to lead Wishard during this most important time.”

At the end of 2003, Wishard administrators faced a projected $40 million deficit. Cost-cutting measures have been implemented and additional funding is being sought to cure the facility’s ailing fiscal situation. But the 1983 IUSM graduate is up to the challenge.

“I am eager to assume this role and I’m optimistic,” says Dr. Harris, who also was named IUSM associate dean of Wishard Affairs. “While I will be working closely with Wishard’s board of trustees and administrative leadership to stabilize our financial future, I embrace the opportunity to work with the physicians and staff to improve the care we provide to the Indianapolis community, particularly the medically vulnerable.”

Dr. Harris completed an internship, residency and fellowship in internal medicine at IUSM, as well as a fellowship in nephrology. She is credited for advancing programs for preventive and therapeutic care and has led research focusing on patients’ reports and evaluations to improve delivery of care.

Matthew Gutwein, president and CEO of the HHC of Marion County, described Dr. Harris as visionary and the right person to lead Wishard. “Lisa loves Wishard, our patients and our mission, and we are fortunate to have her at the helm,” Gutwein says.

Grants Expand IU-MOI aids Research

The success of a two-year program to treat HIV/AIDS in adults and children in Kenya has attracted a one-year, $1.6 million grant from the U.S. Agency for International Development and A $15 million award from the cdc.

The program, Academic Model for the Prevention and Treatment for HIV/AIDS (AMPATH), was created by the Indiana University School of Medicine, the Moi Teaching and Referral Hospital, and the Moi University Faculty of Health Sciences in Kenya.

The new grant will allow IU and Moi physicians to increase the number of HIV-infected people they treat in Kenya from 2,000 to 30,000, and to establish HIV treatment and prevention programs in six rural communities over the next five years.

AMPATH is a model program that attracted the U.S. agency funding after successfully enrolling and treating more than 1,500 patients using modern HIV/AIDS therapy. It also instituted a successful mother-to-child-transmission prevention program in which more than ninety traditional birth attendants have been trained to care for HIV-infected women using preventive interventions. The program has educated community support groups about HIV, the importance of prevention and the need for testing.

Faculty and students also have established a practical, low-cost, high-production ten-acre farm in Kenya to provide high quality macro-nutrition to HIV-infected families.

AMPATH is opening a new facility in May 2004 in urban Kenya for teaching, research and patient care. A second new building will be opened in the rural community of Mosoriot for treatment, counseling, teaching and research. These and other treatment facilities will feature an electronic medical record system to help physicians track patients and provide better care.

In addition to the increase in patients treated and the four new rural programs, the grant will allow AMPATH to:

  • replicate the farm model in two rural sites;
  • develop an enterprise program that will assure sustainable economic security for affected Kenyan families;
  • make the AMPATH electronic medical record system capable of replication in and outside Kenya to support patient care and the uniform reporting of results, teaching and research;
  • fund the additional laboratory services needed to serve a wide region of western Kenya.

The grant also will support a full range of educational programs for medical students, post-graduate physicians and providers of HIV care in Kenya to assure continuation of quality care.

“We could not have made it to this point without the years of support of many private donors in Indiana,” says Robert Einterz, MD, scientific director of the AMPATH program and IUSM assistant dean for international affairs. “The tireless efforts of IU faculty physicians like John Sidle, Bill Tierney and Joe Mamlin have inspired us to keep at this over the past fourteen years.”

Dr. Mamlin retired from the IUSM faculty in 2002 and now works with his Kenyan colleagues on the program. He works with Haroun N.K. Mengech, PB, ChB, director of the Moi Teaching and Referral Hospital; B.O. Khwa-Otsyula, MB, ChB, dean of Moi University Faculty of Health Sciences; and co-director of the program.

See Dean Brater’s message for a more recent award announcement.

Vaccine Program Helps Kenya Kids

Half of the children born in sub-Saharan Africa each year do not receive vaccinations to protect them from common debilitating or deadly diseases. An ambitious venture between IUSM, Moi University Faculty of Health Sciences and Merck & Co. aims to boost the number of children vaccinated.

The Merck Vaccine Network-Africa has granted $200,000 to the School to create a training program in Eldoret, Kenya, which will develop a sustainable workforce of medical professionals skilled in vaccine management, storage and delivery. About ten percent of Kenya’s children die before reaching the age of five, reports the World Health Organization. Many succumb to diseases preventable through vaccinations.

“Working within the framework established at Moi and the strong relationships we have forged with our colleagues and others in Kenya, we expect to provide the necessary training to make this program succeed,” says Edward Liechty, MD, professor of pediatrics and principal investigator for the Merck grant. Fabian Esamai, MD, professor of pediatrics, is principal investigator at Moi, and will work with Dr. Liechty to implement the program.

“By training immunization managers through the MVN-A initiative, we hope to enhance our ability to vaccinate and increase coverage against the eight diseases covered by the extended program on immunizations in my country,” adds Dr. Esamai. The diseases are tuberculosis, diphtheria, pertussis, tetanus, poliomyelitis, measles, hepatitis B and haemophilus influenza type B, which can lead to numerous infections in children.

Roger Roeske, PhD
His Persistence Results in IU First

HE had no idea he would father a drug for prostate cancer when he began his research on contraception thirty years ago. In doing so, he will go down in IU history as the first faculty member to discover the makings of a drug that made it to market.

Dr. Roeske was in his mid-forties when he began his research. Today, at seventy-six, he continues to teach at IUSM and research compounds for age-related disorders such as Alzheimer disease. His research is credited with leading to the development of abarelix – the generic name for Plenaxis™ – an antagonist that blocks the body’s ability to produce testosterone, which enables most prostate cancers to grow. As a result fewer cancer cells are formed, minimizing the disease’s progression and making therapeutic agents more effective.

“Like so many things, this project started in a different direction,” says the professor of biochemistry and biology. “By shifting the focus of my project, the early research was purposeful and provided the momentum for developing a much-needed product.”

Plenaxis was approved for use by the FDA late last year.

Merrill D. Benson, MD
… And So Does His

This IU Physician is the first recipient of the Pasteur-Weizmann-Servier International Prize in Biomedical Research in Paris for his pioneering work on the role amyloid proteins play in the development of a variety of disorders.

Dr. Benson, professor of pathology and laboratory medicine, and of medical and molecular genetics and of medicine, recently was cited for his research on the accumulation of protein fibers in tissues that can disrupt normal organ function. Amyloidosis refers to the disease that causes the deposits and, depending on the type of the amyloid, can lead to heart, kidney and liver failure, as well as other disorders. Dr. Benson is acclaimed for his discovery of protein mutations which lead to Alzheimer and other central nervous system diseases.

The prestigious award, which includes a significant cash prize, is to be presented every three years to a prominent researcher, scientist or physician who has gained international recognition for a biomedical discovery that has resulted in a therapy.

The Pasteur Institute in France is named for Louis Pasteur, the discoverer of the vaccination for rabies. The Weizmann Institute of Science is a leading research and academic organization in Israel. France’s Servier Institute promotes all forms of research and science advancing medicine.